PPARδ-mediated macrophage activation: a matter of fat
نویسندگان
چکیده
منابع مشابه
A transient reversal of miRNA-mediated repression controls macrophage activation
In mammalian macrophages, the expression of a number of cytokines is regulated by miRNAs. Upon macrophage activation, proinflammatory cytokine mRNAs are translated, although the expression of miRNAs targeting these mRNAs remains largely unaltered. We show that there is a transient reversal of miRNA-mediated repression during the early phase of the inflammatory response in macrophages, which lea...
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Introduction Macrophage activation syndrome (MAS) is a rare and life-threatening complication of Kawasaki Disease (KD) that is usually diagnosed at the same time or after KD. We report a case of MAS as the initial manifestation of KD. Case Report A previously healthy 3-year old girl was admitted to the pediatric infectious di...
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245 words) 45 Background Exercise intolerance in heart failure has been linked to impaired 46 skeletal muscle oxidative capacity. Oxidative metabolism and exercise capacity 47 are regulated by PPARδ signaling. We hypothesized that PPARδ stimulation 48 reverts skeletal muscle oxidative dysfunction. 49 Methods Myocardial infarction (MI) was induced in C57BL/6 mice and the 50 development of ventri...
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BACKGROUND IL-33, a member of the IL-1 family of cytokines, provokes Th2-type inflammation accompanied by accumulation of eosinophils through IL-33R, which consists of ST2 and IL-1RAcP. We previously demonstrated that macrophages produce IL-33 in response to LPS. Some immune responses were shown to differ between ST2-deficient mice and soluble ST2-Fc fusion protein-treated mice. Even in anti-ST...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2009
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.003913